Dystrophic Calcification - Symptoms, Causes, Treatment, Metastatic Calcification

Dystrophic calcification is the calcification of necrotic or degenerative cells present at any site of body. This condition resembles to caseous nodules, leiomyoma’s and hyalinized scars. This condition occurs as a response to any tissue injury or necrosis occur during any organ transplantation. Even a minute increase of calcium level in blood can cause dystrophic calcification. The salt of calcium show aggregation in the mitochondria of the necrotic cell where phosphatases gets activated and attach calcium ions to it. The dystrophic calcification is the indication of previous injury of cell at microscopic level.  Cysts and aortic atheroma can show calcification.

Dystrophic Calcification - Symptoms, Causes, Treatment, Metastatic Calcification

Dystrophic Calcification Causes

There are many causes behind the dystrophic calcification. Some of them are as follows:

  • Chronic kidney failure due to necrosis occurred.
  • Hyperthyroidism both primary and secondary can cause dystrophic calcification.
  • In bowel syndrome, excessive absorption of calcium is the cause behind dystrophic calcification.
  • Hypophosphotasia may be the cause, as phosphate is responsible for aggregating calcium ions.
  • Malignancies like parathyroid adenoma, multiple myeloma, lymphoma, leukemia, carcinoma and sarcoma all are the causes behind dystrophic calcification.
  • Any lesion occur at bones or tissues of body
  • Tubular acidosis of kidney is also the indirect cause behind dystrophic calcification.

Dystrophic Calcification Symptoms

The symptoms associated with dystrophic calcification are as follows:

  • The appearance of bone at any site of body is the visible symptom associated with dystrophic calcification.
  • Due to dystrophic calcification, the calcium deposit level increases in arteries which ultimately makes them harder and block them with calcium deposits causing atherosclerosis, thereby hindering blood flow and normal activity of heart via causing heart attack or heart stroke.
  • Calcium aggregates around the muscles cause the pain and make it unable to move freely along with inflammation at the site of calcium deposits,
  • Phlebolith is the condition in which blood clots are formed can appear due to dystrophic calcification.

Dystrophic Calcification Treatment

The dystrophic calcification normally is non treatable and also can’t take it back. A technique known as calcific band keratotherapy is done to remove the calcification around cornea of eye. Only the complications associated with dystrophic calcification can be treated. The treatment option are selected on the basis of defect in calcium metabolism. The complications associated with treatment are:

  • Deformity of the organ, muscle or bone.
  • If it is in eye, then pain in eye and sometimes vision loss can occur.
  • Peripheral artery disease can occur If it is not treated.

Dystrophic Calcification vs Metastatic Calcification

The main difference noticed between these two terms is Dystrophic calcification is seen in area only having necrosis but metastatic is a condition associated with hypercalcemia. The dystrophic calcification occurs in necrotic cells well metastatic calcification can occur in normal cells of body. It can occur throughout the body.

As dystrophic name indicates dead or damaged. The both types of calcification are associated with phosphate crystals responsible for depositing calcium ions in body. In metastasis calcification the effected cells are excreting acids after absorbing calcium ions in body due to an alkaline component present inside body.
Dystrophic Calcification - Symptoms, Causes, Treatment, Metastatic Calcification Dystrophic Calcification - Symptoms, Causes, Treatment, Metastatic Calcification Reviewed by Simon Albert on April 17, 2017 Rating: 5
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